Human Leukocyte Antigen Class I and II Variants in Yemeni Patients with Chronic Renal Failure

Authors

  • Abdullah Saleh Al-Samawi Department of Pathology, Faculty of Medicine and Health Sciences, Sana'a, Yemen
  • Haitham Abdulwahab Masood HLA Typing Unit, Al-Thawra General Hospital, Sana'a, Yemen
  • Hassan Abdulwahab Al-Shamahy Department of Microbiology, Faculty of Medicine and Health Sciences, Sana'a, Yemen
  • Ibrahiem Husain El-Nono Urology and Nephrology Center Al-Thawra General Hospital; Department of Urology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen
  • Mogahid Yahi'a Nassar Department of Clinical Pathology, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana'a, Yemen
  • Nagieb Waza'a Abu Asba Urology and Nephrology Center, Al-Thawra General Hospital; Department of Nephrology, Faculty of Medicine and Health Sciences, Sana'a, Yemen
Abstract:

Background: Human leukocyte antigens (HLAs) are found to be significant genetic factors concerning the susceptibility of an individual to certain diseases. Objective: To determine the association between variants of class I (A and B) and class II (DRB1) HLA alleles and chronic renal failure (CRF), compared with healthy controls, in Yemen. Methods: A case-control study in the Urology and Nephrology Center at Al-Thawra University Hospital in Sana’a, Yemen was carried out between January 2013 and December 2015 and included 187 CRF patients, and 194 healthy controls visiting the same center for kidney donation. All CRF patients in the study were on haemodialysis. The control group was confirmed to be healthy following a clinical examination by specialist physicians. Among both patients and controls, HLA class I (A and B) and class II (DRB1) HLA typing was carried out by Sequence Specific Primers (SSP) polymerase chain reaction (PCR). Results: There was a significant protective function for HLA-A*30 gene (CRF 9.1% vs. con 16%, p=0.045) against CRF development. There was a high frequency of HLA-A*02, HLA-B*51 and HLA-DRB1*04 alleles in both patients and controls. Conclusion: No HLAs were located to have a significant association with genetic tendency to CRF in the current study population, however, certain HLA alleles, for instance in HLA-A*30, could be considered protective against CRF progress.

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Journal title

volume 14  issue 3

pages  240- 249

publication date 2017-09-01

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